Viedma ripening is a process that combines abrasive grinding of a slurry of crystals with solution‐phase racemization, resulting in solid‐phase deracemization. One of the major disadvantages of Viedma ripening is that the desired compound needs to crystallize as a racemic conglomerate, accounting for only 5–10 % of all chiral molecules. Herein, we show that use of a chiral additive causes deracemization under conditions, in which the compound normally crystallizes as a racemic compound. Although this concerns a single example, it is envisioned that through this new approach the scope of Viedma ripening can be significantly expanded.

中文翻译：

---

使用量身定制的添加剂对消旋化合物进行消旋

Viedma成熟是将晶体浆料的研磨研磨与固溶相消旋相结合的过程，从而导致固相脱硫。Viedma熟化的主要缺点之一是所需的化合物需要结晶为外消旋的团聚体，仅占所有手性分子的5-10％。在此，我们表明使用手性添加剂会在该化合物正常结晶为外消旋化合物的条件下引起脱硫。尽管这仅涉及一个示例，但可以预见，通过这种新方法，Viedma成熟的范围可以大大扩展。