Modulation of BACE1 Activity by Chemically Modified Aptamers,ChemBioChem

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Modulation of BACE1 Activity by Chemically Modified Aptamers
ChemBioChem ( IF 2.6 ) Pub Date : 2018-02-19 , DOI: 10.1002/cbic.201700461
Cécile Gasse ₁ , Marwa Zaarour ₁ , Sam Noppen ₂ , Mikhail Abramov ₃ , Philippe Marlière ₄ , Sandra Liekens ₂ , Bart De Strooper _{5,

6,

7} , Piet Herdewijn _{1,

3}

Affiliation

Xenonucleic acids—a good thymine substitute: SELEX was used to select an aptamer that binds and inhibits, but also activates, BACE1, a therapeutic target in Alzheimer's disease, in a concentration‐dependent manner. This aptamer was obtained by using 5‐chloro‐dUTP in place of dTTP during the selection process, opening a way to a new xenobiotic.