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Synthesis of Trifluoroacetyl-Substituted Cyclopropanes Using Onium Ylides
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-01-22 , DOI: 10.1002/ejoc.201701699
Michael Winter 1 , Christina Gaunersdorfer 1 , Lukas Roiser 1 , Katharina Zielke 1 , Uwe Monkowius 2 , Mario Waser 1
Affiliation  

The use of carbonyl‐stabilized ammonium‐ and sulfonium ylides allows for the synthesis of highly‐functionalized trifluoroacetyl‐substituted cyclopropanes. It turned out that the diastereoselectivities strongly depend on the nature of the chosen ylide and the employed base. The products could be obtained in good yields under operationally simple conditions.

中文翻译:

使用鎓叶立德合成三氟乙酰基取代的环丙烷

使用羰基稳定的铵叶立德和锍叶立德可以合成高度官能化的三氟乙酰基取代的环丙烷。事实证明,非对映选择性很大程度上取决于所选叶立德和所用碱的性质。在操作简单的条件下可以以良好的产率获得产物。
更新日期:2018-01-22
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