Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging†,Journal of Materials Chemistry B

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Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging†
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2018-01-12 00:00:00 , DOI: 10.1039/c7tb02912h
F Zamberlan ₁ , L Turyanska , A Patanè , Z Liu , H E L Williams , M W Fay , P A Clarke , Y Imamura , T Jin , T D Bradshaw , N R Thomas , A M Grabowska

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The short shelf-life of water-soluble quantum dots (QDs) due to colloidal instability represents a major drawback to their exploitation. This work examines the colloidal stability of PbS nanoparticles capped with dihydrolipoic acid–polyethylene glycol (DHLA–PEG) ligands terminated with functional groups such as –NH₂, –COOH, OMe and –N₃. and their application for in vivo imaging. We prove a mechanism of colloidal instability and develop a strategy to produce for the first time stable PEG-capped PbS quantum dots with high quantum yield and optical emission in the first and the second near-infrared (NIR) windows of low absorption of biological tissues. The NIR imaging of in vivo biodistribution is demonstrated at wavelengths >1000 nm, with benefits of reduced tissue absorption and light scattering. The stability, biocompatibility and potential for further QD functionalization open up realistic prospects for non-invasive bioimaging applications.

中文翻译：

稳定的 DHLA-PEG 加帽 PbS 量子点：从合成到近红外生物医学成像†

由于胶体不稳定性，水溶性量子点 (QD) 的保质期短是其开发的主要缺点。这项工作检查了用二氢硫辛酸-聚乙二醇 (DHLA-PEG) 配体封端的 PbS 纳米粒子的胶体稳定性，这些配体以–NH ₂、–COOH、OMe 和–N ₃等官能团封端。及其在体内成像中的应用。我们证明了胶体不稳定性的机制，并开发了一种策略，首次在生物组织的低吸收率的第一和第二近红外 (NIR) 窗口中生产具有高量子产率和光发射的稳定的 PEG 封端的 PbS 量子点. 体内近红外成像生物分布在>1000 nm 的波长下得到证明，具有减少组织吸收和光散射的好处。稳定性、生物相容性和进一步 QD 功能化的潜力为非侵入性生物成像应用开辟了现实前景。

更新日期：2018-01-12

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