An efficient method to construct azapolycycles via directing group participated benzylic C(sp³)–H/C(sp²)–H cross-dehydrogenative coupling reactions is described. The reaction proceeded through a palladium catalyzed C(sp³)–H activation followed by coupling with a C(sp²)–H bond of quinoline to afford the azapolycyclic compounds. The reaction works with a broad substrate scope affording the products in moderate to good yields with excellent diastereoselectivities. Control experiments further supported the proposed mechanism.

中文翻译：

---

指导小组参与的苄基C（sp ³）–H / C（sp ²）–H交叉脱氢偶联（CDC）：氮杂多环的合成

描述了一种通过引导基团参与的苄基C（sp ³）–H / C（sp ²）–H交叉脱氢偶联反应来构建氮杂多环的有效方法。反应通过钯催化的C（sp ³）–H活化进行，然后与喹啉的C（sp ²）–H键偶联，得到氮杂多环化合物。该反应在宽范围的底物范围内进行，从而以中等至良好的产率提供了优异的非对映选择性。控制实验进一步支持了所提出的机制。