The succinate dehydrogenase inhibitor (SDHI) fungicides have been extensively used in agriculture, and some of their potential ecological risks to aquatic organisms have been demonstrated recently. Sedaxane (SDX) is a broad spectrum SDHI fungicide. Despite being extensively used in environment, little is known about its potential developmental effect in zebrafish embryo. This study examined the effects of which SDX triggered in zebrafish through embryonic development assessments. Results show that SDX induced mortality, hatch delay and failure in zebrafish embryos, which were concentration dependent. In addition, several developmental abnormalities were observed at 2 mg/L and higher concentrations, including edema, microcephaly, body deformation, and swim bladder not fully inflated. SDX exposure influenced reactive oxygen species, malondialdehyde, peroxidase, glutathione S-transferase, superoxide dismutase and glutathione in live larvae, which indicated that oxidative stress was caused in zebrafish. Furthermore, SDX induced decrease of succinate dehydrogenase activity in zebrafish larvae. These results provide toxicological data of SDX on developing zebrafish embryo, which could be help for further understanding the potential risk on the environment.

琥珀酸脱氢酶抑制剂（SDHI）杀真菌剂已广泛用于农业，最近已证明了它们对水生生物的潜在生态风险。Sedaxane（SDX）是广谱SDHI杀真菌剂。尽管已广泛用于环境中，但对其在斑马鱼胚胎中的潜在发育作用知之甚少。这项研究通过胚胎发育评估检查了SDX在斑马鱼中引发的影响。结果表明，SDX诱导斑马鱼胚胎的死亡率，孵化延迟和衰竭，这与浓度有关。此外，在2 mg / L和更高的浓度下观察到一些发育异常，包括水肿，小头畸形，身体变形和游泳膀胱未完全膨胀。SDX暴露会影响活性氧，丙二醛，幼虫体内的过氧化物酶，谷胱甘肽S-转移酶，超氧化物歧化酶和谷胱甘肽均表明斑马鱼体内存在氧化应激。此外，SDX诱导斑马鱼幼虫的琥珀酸脱氢酶活性降低。这些结果提供了SDX对斑马鱼胚胎发育的毒理学数据，这可能有助于进一步了解环境的潜在风险。