The impact of agrimoniin, sanguiin H-6, rugosins D and A, tellimagrandin I, and pedunculagin on Adriamycin-resistant (MCF-7/Adr) and wild-type (MCF-7/wt) human breast cancer cell lines was evaluated with MTT assay. An inhibitory effect on MCF-7/wt cells viability grew stronger with the number of functional units: hexahydroxydiphenoyl (HHDP) group – releasable in the form of ellagic acid (EA), and HHDP derivatives (releasable in the form of EA derivatives). Thus agrimoniin (with five units) was the most active, pedunculagin and rugosin D (with two units each) exhibited medium impact, and rugosin A and tellimagrandin I (both with 1 unit) were the least active. Sanguiin H-6 was the only compound which inhibited MCF-7/Adr cells. It might be hypothesized that the characteristic for sanguiin H-6 structural sanguisorboyl unit contributed to the effect on MCF-7/Adr cells.

用以下方法评估了农杆菌素，血红素H-6，果胶D和A，替格马汀I和pedunculagin对耐阿霉素（MCF-7 / Adr）和野生型（MCF-7 / wt）的人乳腺癌细胞系的影响MTT测定。随着功能单元数量的增加，对MCF-7 / wt细胞活力的抑制作用变得更强：六羟基二苯甲酰基（HHDP）基团-以鞣花酸（EA）形式释放，以及HHDP衍生物（以EA衍生物形式释放）。因此，Agrimoniin（五个单位）是最活跃的，pedunculagin和rugosin D（每个两个单位）表现出中等的冲击力，而rugosin A和Tellimagrandin I（两个都一个单位）的活性最低。血红素H-6是唯一抑制MCF-7 / Adr细胞的化合物。