Synthesis of N‐Heterocyclic Carbene–PdII–2‐Methyl‐4,5‐dihydrooxazole Complexes and Their Application Toward Highly Chemoselective Mono‐Suzuki–Miyaura Coupling of Dichlorobenzenes,Asian Journal of Organic Chemistry

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Synthesis of N‐Heterocyclic Carbene–PdII–2‐Methyl‐4,5‐dihydrooxazole Complexes and Their Application Toward Highly Chemoselective Mono‐Suzuki–Miyaura Coupling of Dichlorobenzenes
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2018-02-01 , DOI: 10.1002/ajoc.201800001
Kai-Xin Sun ₁ , Qian-Wei He ₁ , Bin-Bin Xu ₁ , Xiang-Ting Wu ₂ , Jian-Mei Lu ₁

Affiliation

A series of N‐heterocyclic carbene–palladium(II)–2‐methyl‐4,5‐dihydrooxazole complexes was synthesized in a one‐step process, one of which facilitated high chemoselectivity in the mono‐Suzuki–Miyaura coupling of dichlorobenzenes. Further transformations of the mono‐coupling products catalyzed by this complex were also investigated, which gave the desired C−C and C−N coupling products in excellent yields. The reported methodology allows the conversion of readily available dichlorobenzenes into synthetically useful chlorobiphenyls.

中文翻译：

N-杂环碳烯-PdII-2-甲基-4,5-二氢恶唑配合物的合成及其在二氯苯的高化学选择性单铃木-Miyaura偶联中的应用

一步合成了一系列N-杂环卡宾-钯（II）-2-甲基-4,5-二氢恶唑配合物，其中一个促进了二氯苯的单铃木-宫浦偶联反应的高化学选择性。还研究了这种配合物催化的单偶联产物的进一步转化，从而以优异的收率获得了所需的CC和CN偶联产物。所报道的方法允许将容易获得的二氯苯转化为合成上有用的氯联苯。

更新日期：2018-02-01

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