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Voltammetric Detection of Catecholamine Metabolites Using Tröger's Base Modified Electrode
Electroanalysis ( IF 2.7 ) Pub Date : 2018-01-12 , DOI: 10.1002/elan.201700635 Tatiana V. Shishkanova 1, 2 , Gabriela Broncová 1 , Přemysl Fitl 3 , Vladimír Král 1, 2 , Jiří Barek 4
Electroanalysis ( IF 2.7 ) Pub Date : 2018-01-12 , DOI: 10.1002/elan.201700635 Tatiana V. Shishkanova 1, 2 , Gabriela Broncová 1 , Přemysl Fitl 3 , Vladimír Král 1, 2 , Jiří Barek 4
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The advantage of surface modification of voltammetric sensor for determination of catecholamine metabolites such as vanillyl mandelic acid (VMA) and homovanillic acid (HVA) is discussed. The amino‐substituted coumarin derivative of Tröger's base was deposi‐ted on a graphite screen‐printed electrode (poly(CTB)/G/SPE) cycling the electrode potential between 0 and 1.2 V in 5 mL CH2Cl2 containing 1×10−3 mol L−1 tetrabutylammonium tetrafluoroborate and 20 μL 0.1 mol L−1 HCl. The poly(CTB) functions as both a selective recognition and pre‐concentrator agent for catecholamine metabolites. The high sensitivity of the voltammetric sensor coated by a poly(CTB) film toward VMA was achieved despite the high structural similarity between the two tested metabolites. We presume the voltammetric detection of these species is based on selective binding by a poly(CTB) film supported by its good adherence to the electrode substrate. The voltammetric signals of VMA were observable in the concentration range 10–100 μmol L−1 (LOD=0.2 μmol L−1) and 20–60 μmol L−1 (LOD=10 μmol L−1) in the model and synthethic urine samples, respectively.
中文翻译：
使用Tröger碱修饰电极伏安法检测儿茶酚胺代谢物
讨论了伏安传感器表面修饰用于测定儿茶酚胺代谢产物（如香草基扁桃酸（VMA）和高香草酸（HVA））的优势。Tröger碱的氨基取代香豆素衍生物沉积在石墨丝网印刷电极（poly（CTB）/ G / SPE）上，在5 mL含1×10的CH 2 Cl 2中使电极电势在0至1.2 V之间循环-3 mol L -1四氟硼酸四丁基铵和20μL0.1 mol L -1盐酸。聚（CTB）可作为儿茶酚胺代谢物的选择性识别剂和预浓缩剂。尽管两种被测代谢物之间具有高度的结构相似性，但仍获得了由聚（CTB）膜涂覆的伏安传感器对VMA的高灵敏度。我们假设这些物质的伏安检测是基于聚（CTB）膜的选择性结合，而聚（CTB）膜对电极基材具有良好的粘附性。VMA的伏安信号分别在浓度范围为10-100微摩尔大号观察到-1（LOD = 0.2微摩尔大号-1）和20-60微摩尔大号-1（LOD = 10微摩尔大号-1在模型和synthethic尿）样本。
更新日期：2018-01-12
中文翻译：
使用Tröger碱修饰电极伏安法检测儿茶酚胺代谢物
讨论了伏安传感器表面修饰用于测定儿茶酚胺代谢产物（如香草基扁桃酸（VMA）和高香草酸（HVA））的优势。Tröger碱的氨基取代香豆素衍生物沉积在石墨丝网印刷电极（poly（CTB）/ G / SPE）上，在5 mL含1×10的CH 2 Cl 2中使电极电势在0至1.2 V之间循环-3 mol L -1四氟硼酸四丁基铵和20μL0.1 mol L -1盐酸。聚（CTB）可作为儿茶酚胺代谢物的选择性识别剂和预浓缩剂。尽管两种被测代谢物之间具有高度的结构相似性，但仍获得了由聚（CTB）膜涂覆的伏安传感器对VMA的高灵敏度。我们假设这些物质的伏安检测是基于聚（CTB）膜的选择性结合，而聚（CTB）膜对电极基材具有良好的粘附性。VMA的伏安信号分别在浓度范围为10-100微摩尔大号观察到-1（LOD = 0.2微摩尔大号-1）和20-60微摩尔大号-1（LOD = 10微摩尔大号-1在模型和synthethic尿）样本。
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