Anti-Alzheimers activity and molecular mechanism of albumin-derived peptides against AChE and BChE,Food & Function

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Anti-Alzheimers activity and molecular mechanism of albumin-derived peptides against AChE and BChE
Food & Function ( IF 5.1 ) Pub Date : 2018-01-12 00:00:00 , DOI: 10.1039/c7fo01462g
Zhipeng Yu _{1,

2,

3,

4} , Sijia Wu _{1,

2,

3,

4} , Wenzhu Zhao _{1,

2,

3,

4} , Long Ding _{4,

5,

6,

7} , Yue Fan _{1,

2,

3,

4} , David Shiuan _{1,

2,

3,

4} , Jingbo Liu _{4,

5,

6,

7} , Feng Chen _{8,

9,

10,

11}

Affiliation

Alzheimer's disease (AD) is a global health issue affecting millions of elderly people worldwide. The aim of the present study was to identify novel anti-AD peptides isolated from albumin. Anti-AD activities of the peptides were evaluated via inhibitory activities on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Furthermore, the potential molecular mechanisms of the KLPGF/AChE were investigated by CDOCKER of Discovery studio 2017. The results revealed that peptide KLPGF could effectively inhibit AChE with an inhibition rate of 61.23% at a concentration of 50 μg mL⁻¹. In addition, the peptide KLPGF came in contact with acylation sites and peripheral anion sites of AChE. The present study demonstrates that the peptide KLPGF could become a potential functional food intervention in AD.

中文翻译：

白蛋白衍生肽对AChE和BChE的抗阿尔茨海默氏病活性和分子机制

阿尔茨海默氏病（AD）是一个全球性的健康问题，影响着全球数百万的老年人。本研究的目的是鉴定从白蛋白分离的新型抗AD肽。通过对乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BChE）的抑制活性来评估肽的抗AD活性。此外，Discovery studio 2017的CDOCKER研究了KLPGF / AChE的潜在分子机制。结果表明，肽KLPGF在50μgmL ^-1的浓度下可以有效抑制AChE，抑制率为61.23％。。另外，肽KLPGF与AChE的酰化位点和外围阴离子位点接触。本研究表明，肽KLPGF可能成为AD中潜在的功能性食品干预措施。

更新日期：2018-01-12

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