Protective effect of rosmarinic acid and carnosic acid against streptozotocin-induced oxidation, glycation, inflammation and microbiota imbalance in diabetic rats,Food & Function

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Protective effect of rosmarinic acid and carnosic acid against streptozotocin-induced oxidation, glycation, inflammation and microbiota imbalance in diabetic rats
Food & Function ( IF 5.1 ) Pub Date : 2018-01-12 00:00:00 , DOI: 10.1039/c7fo01508a
Juanying Ou ₁ , Junqing Huang , Danyue Zhao , Bin Du , Mingfu Wang

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This study evaluated the protective effects of two rosemary components, rosmarinic acid (RA) and carnosic acid (CA), against hypoglycemia, hyperlipidemia, oxidative stress and an imbalanced gut microbiota architecture in diabetic rats. Treatment with RA and CA (30 mg kg⁻¹) decreased the levels of fasting plasma glucose (23.7%, 15.6%), total cholesterol (30.4%, 14.1%) and triglyceride (65.7%, 47.8%) at 15 weeks. RA and CA also exhibited an anti-oxidative and anti-glycative effect by lowering the formation of malondialdehyde and advanced glycation end products. In addition, they showed protective effects against tissue damage and inflammation in the abdominal aorta, based on microscopic observations and the analysis of protein expression. Finally, the prebiotic effects of RA and CA on gut microbiota were demonstrated by increasing the population of diabetes-resistant bacteria and decreasing the amounts of diabetes-sensitive bacteria. Overall, RA showed a stronger protective effect than CA in mitigating diabetic symptoms in rats.

中文翻译：

迷迭香酸和鼠尾草酸对链脲佐菌素诱导的糖尿病大鼠氧化、糖化、炎症和微生物失衡的保护作用

本研究评估了两种迷迭香成分迷迭香酸（RA）和鼠尾草酸（CA）对糖尿病大鼠的低血糖、高脂血症、氧化应激和肠道菌群结构失衡的保护作用。 15周时，RA和CA（30 mg kg ^-1 ）治疗降低了空腹血糖（23.7%，15.6%）、总胆固醇（30.4%，14.1%）和甘油三酯（65.7%，47.8%）的水平。 RA 和 CA 还通过降低丙二醛和晚期糖化终产物的形成而表现出抗氧化和抗糖化作用。此外，根据显微镜观察和蛋白质表达分析，它们显示出对腹主动脉组织损伤和炎症的保护作用。最后，通过增加抗糖尿病细菌的数量和减少糖尿病敏感细菌的数量，证明了 RA 和 CA 对肠道微生物群的益生元作用。总体而言，RA 在减轻大鼠糖尿病症状方面表现出比 CA 更强的保护作用。

更新日期：2018-01-12

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