A Cu‐catalyzed cascade oxidative radical process of β‐keto sulfones with alcohols has been achieved by using oxygen as an oxidant. In this reaction, β‐keto sulfones were converted into sulfinate esters under the oxidative conditions via cleavage of C−S bond. Experimental and computational studies demonstrate that a new pathway is involved in this reaction, which proceeds through the formation of the key four‐coordinated Cu^II intermediate, O−O bond homolysis induced C−S bond cleavage and Cu‐catalyzed esterification to form the final products. This reaction provides a new strategy to sulfonate esters and enriches the research content of C−S bond cleavage and transformations.

中文翻译：

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β-酮基砜与铜的C-S键断裂铜催化氧化反应：反应发展及机理研究

通过使用氧气作为氧化剂，实现了β-酮砜与醇的Cu催化级联氧化自由基过程。在该反应中，β-酮砜在氧化条件下通过裂解C-S键转化为亚磺酸酯。实验和计算研究表明，该反应涉及新途径，该过程通过关键的四配位Cu ^II中间体的形成，O-O键均溶引起的CS键断裂和Cu催化的酯化反应形成最终途径。产品。该反应为磺化酯提供了新的策略，丰富了CS键断裂和转化的研究内容。