AbstractThe authors present a nonenzymatic sensor for glucose that has an exceedingly low working potential which makes the sensor highly selective over other electroactive species. The sensor is based on the use of a glassy carbon electrode (GCE) that was modified with a nanoporous PdAuNi alloy (np-PdAuNi). The PdAuNi alloy nanostructure displays enhanced electrocatalytic activity for glucose oxidation (compared to PdNi alloys). The modified GCE enables amperometric sensing of glucose at a typical working electrode potential of 0.0 V vs. SCE in solutions of pH 13 containing 0.1 M NaCl. Response is linear in the 5 to 100 μM concentration range, with a 1.7 μM detection limit (at an S/N ratio of 3). For higher concentrations deviations from linearity were found. The method is selective and reproducible. The modified electrode was applied to the determination of glucose in human serum. Graphical AbstractNanoporous PdAuNi alloy with three-dimensional bicontinuous nanosponge architecture was successfully prepared via chemical dealloying. The electrochemical nonenzymatic glucose sensor shows a low working potential, wide linear range, good sensitivity, low detection limit and excellent selectivity.

中文翻译：

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使用纳米多孔 PdAuNi 三元合金在非常低的工作电位下对葡萄糖进行安培非酶传感

摘要作者提出了一种葡萄糖的非酶传感器，它具有极低的工作电位，这使得该传感器对其他电活性物质具有高度选择性。该传感器基于使用经过纳米多孔 PdAuNi 合金 (np-PdAuNi) 改性的玻璃碳电极 (GCE)。PdAuNi 合金纳米结构显示出增强的葡萄糖氧化电催化活性（与 PdNi 合金相比）。在含有 0.1 M NaCl 的 pH 13 溶液中，改进的 GCE 能够在 0.0 V 与 SCE 的典型工作电极电位下对葡萄糖进行电流检测。响应在 5 到 100 μM 浓度范围内呈线性，检测限为 1.7 μM（信噪比为 3）。对于更高的浓度，发现了与线性的偏差。该方法具有选择性和可重复性。改进后的电极用于测定人血清中的葡萄糖。图形摘要通过化学脱合金成功制备了具有三维双连续纳米海绵结构的纳米多孔PdAuNi合金。电化学非酶葡萄糖传感器具有低工作电位、宽线性范围、良好的灵敏度、低检测限和优异的选择性。