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Resonance Energy Transfer-Promoted Photothermal and Photodynamic Performance of Gold–Copper Sulfide Yolk–Shell Nanoparticles for Chemophototherapy of Cancer
Nano Letters ( IF 9.6 ) Pub Date : 2018-01-17 00:00:00 , DOI: 10.1021/acs.nanolett.7b04162 Yun Chang 1, 2 , Yan Cheng 1 , Yanlin Feng 1, 3 , Hui Jian 1 , Li Wang 4 , Xiaomin Ma 4 , Xi Li 4 , Haiyuan Zhang 1, 2, 3
Nano Letters ( IF 9.6 ) Pub Date : 2018-01-17 00:00:00 , DOI: 10.1021/acs.nanolett.7b04162 Yun Chang 1, 2 , Yan Cheng 1 , Yanlin Feng 1, 3 , Hui Jian 1 , Li Wang 4 , Xiaomin Ma 4 , Xi Li 4 , Haiyuan Zhang 1, 2, 3
Affiliation
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Gold (Au) [email protected]@copper sulfide (CuS) shell (Au–CuS) yolk–shell nanoparticles (YSNPs) were prepared in the present study for potential chemo-, photothermal, and photodynamic combination therapy, so-called “chemophototherapy”. The resonance energy transfer (RET) process was utilized in Au–CuS YSNPs to achieve both enhanced photothermal and photodynamic performance compared with those of CuS hollow nanoparticles (HNPs). A series of Au nanomaterials as cores that had different localized surface plasmon resonance (LSPR) absorption peaks at 520, 700, 808, 860, and 980 nm were embedded in CuS HNPs to screen the most effective Au–CuS YSNPs according to the RET process. Thermoresponsive polymer was fabricated on these YSNPs’ surface to allow for controlled drug release. Au808–CuS and Au980–CuS YSNPs were found capable of inducing the largest temperature elevation and producing the most significant hydroxyl radicals under 808 and 980 nm laser irradiation, respectively, which could accordingly cause the most severe 4T1 cell injury through oxidative stress mechanism. Moreover, doxorubicin-loaded (Dox-loaded) P(NIPAM-co-AM)-coated Au980–CuS (p-Au980–[email protected]) YSNPs could more efficiently kill cells than unloaded particles upon 980 nm laser irradiation. After intravenous administration to 4T1 tumor-bearing mice, p-Au980–CuS YSNPs could significantly accumulate in the tumor and effectively inhibit the tumor growth after 980 nm laser irradiation, and p-Au980–[email protected] YSNPs could further potentiate the inhibition efficiency and exhibit excellent in vivo biocompatibility. Taken together, this study sheds light on the rational design of Au–CuS YSNPs to offer a promising candidate for chemophototherapy.
中文翻译：
共振能量转移促进金铜硫化物蛋黄壳纳米粒子光化学和光动力学性能的癌症化学光疗。
在本研究中制备了金（Au）[受电子邮件保护] @硫化铜（CuS）壳（Au–CuS）蛋黄壳纳米颗粒（YSNPs），用于潜在的化学，光热和光动力联合治疗，即所谓的“化学光疗” ”。与CuS中空纳米粒子（HNPs）相比，Au–CuS YSNPs中利用了共振能量转移（RET）过程来实现增强的光热和光动力性能。一系列以Au为核心的Au纳米材料在520、700、808、860和980 nm处具有不同的局部表面等离子体共振（LSPR）吸收峰，从而根据RET方法筛选出最有效的Au–CuS YSNP 。在这些YSNP的表面上制造了热敏性聚合物，以实现药物的受控释放。Au 808 –CuS和Au 980发现CuS YSNPs能够分别在808和980 nm激光照射下引起最大的温度升高并产生最显着的羟基自由基，从而可能通过氧化应激机制导致最严重的4T1细胞损伤。此外，负载阿霉素的（装载DOX）P（NIPAM-共-AM）包被的金980 -CuS（p -Au 980 - [电子邮件保护]）YSNPs可以更有效地杀死细胞比在980nm的激光照射卸载颗粒。在对4T1荷瘤小鼠进行静脉给药后，p -Au 980 -CuS YSNPs可以在肿瘤中大量积聚，并在980 nm激光照射后有效抑制肿瘤的生长，而p-Au 980 – [受电子邮件保护] YSNPs可以进一步增强抑制效率，并具有出色的体内生物相容性。综上所述，本研究揭示了Au-CuS YSNPs的合理设计，为化学光疗提供了有希望的候选人。
更新日期：2018-01-17
中文翻译：
共振能量转移促进金铜硫化物蛋黄壳纳米粒子光化学和光动力学性能的癌症化学光疗。
在本研究中制备了金（Au）[受电子邮件保护] @硫化铜（CuS）壳（Au–CuS）蛋黄壳纳米颗粒（YSNPs），用于潜在的化学，光热和光动力联合治疗，即所谓的“化学光疗” ”。与CuS中空纳米粒子（HNPs）相比，Au–CuS YSNPs中利用了共振能量转移（RET）过程来实现增强的光热和光动力性能。一系列以Au为核心的Au纳米材料在520、700、808、860和980 nm处具有不同的局部表面等离子体共振（LSPR）吸收峰，从而根据RET方法筛选出最有效的Au–CuS YSNP 。在这些YSNP的表面上制造了热敏性聚合物，以实现药物的受控释放。Au 808 –CuS和Au 980发现CuS YSNPs能够分别在808和980 nm激光照射下引起最大的温度升高并产生最显着的羟基自由基，从而可能通过氧化应激机制导致最严重的4T1细胞损伤。此外，负载阿霉素的（装载DOX）P（NIPAM-共-AM）包被的金980 -CuS（p -Au 980 - [电子邮件保护]）YSNPs可以更有效地杀死细胞比在980nm的激光照射卸载颗粒。在对4T1荷瘤小鼠进行静脉给药后，p -Au 980 -CuS YSNPs可以在肿瘤中大量积聚，并在980 nm激光照射后有效抑制肿瘤的生长，而p-Au 980 – [受电子邮件保护] YSNPs可以进一步增强抑制效率，并具有出色的体内生物相容性。综上所述，本研究揭示了Au-CuS YSNPs的合理设计，为化学光疗提供了有希望的候选人。
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