Three novel tricyclic diamines (1,7-diazaisoadamantane, 1,5-diazaisoadamantane and 1,6-diazahomobrendane) were prepared. A flexible synthetic strategy was employed which used flat, aromatic azaindoles as the starting materials. The requisite azaindoles were prepared by a tandem Sonogashira coupling/intramolecular cyclization reaction. Ring saturation, appropriate functionalization and intramolecular alkylation provided the three novel tricyclic diamines cores.

中文翻译：

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新型三环二胺2. 1,7-二氮杂异金刚烷，1,5-二氮杂异金刚烷和1,6-二氮杂均丁烯的合成

制备了三种新颖的三环二胺（1，7-二氮杂异金刚烷，1，5-二氮杂异金刚烷和1，6-二氮杂异丁烯）。采用了灵活的合成策略，该策略使用扁平的芳族氮杂吲哚作为起始原料。通过串联的Sonogashira偶联/分子内环化反应制备必需的氮杂吲哚。环饱和，适当的官能化和分子内烷基化提供了三个新颖的三环二胺核。