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Novel tricyclic diamines 2. Synthesis of 1,7-diazaisoadamantane, 1,5-diazaisoadamantane and 1,6-diazahomobrendane
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2018-01-11 , DOI: 10.1016/j.tetlet.2018.01.028
Ivar M. McDonald , Robert Mate , Alicia Ng , Hyunsoo Park , Richard E. Olson

Three novel tricyclic diamines (1,7-diazaisoadamantane, 1,5-diazaisoadamantane and 1,6-diazahomobrendane) were prepared. A flexible synthetic strategy was employed which used flat, aromatic azaindoles as the starting materials. The requisite azaindoles were prepared by a tandem Sonogashira coupling/intramolecular cyclization reaction. Ring saturation, appropriate functionalization and intramolecular alkylation provided the three novel tricyclic diamines cores.



中文翻译:

新型三环二胺2. 1,7-二氮杂异金刚烷,1,5-二氮杂异金刚烷和1,6-二氮杂均丁烯的合成

制备了三种新颖的三环二胺(1,7-二氮杂异金刚烷,1,5-二氮杂异金刚烷和1,6-二氮杂异丁烯)。采用了灵活的合成策略,该策略使用扁平的芳族氮杂吲哚作为起始原料。通过串联的Sonogashira偶联/分子内环化反应制备必需的氮杂吲哚。环饱和,适当的官能化和分子内烷基化提供了三个新颖的三环二胺核。

更新日期:2018-01-11
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