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Obesity Impairs Oligopeptide/Amino Acid‐Induced Ghrelin Release and Smooth Muscle Contractions in the Human Proximal Stomach
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2018-02-12 , DOI: 10.1002/mnfr.201700804
Laurien Vancleef 1 , Theo Thijs 1 , Florence Baert 1 , Laurens J. Ceulemans 1 , Emilio Canovai 2 , Qiaoling Wang 1 , Sandra Steensels 1 , Anneleen Segers 1 , Ricard Farré 1 , Jacques Pirenne 1 , Matthias Lannoo 3 , Jan Tack 1 , Inge Depoortere 1
Affiliation  

The satiation properties of proteins involve effects on gut peptide release and gastrointestinal motility which may be altered during obesity. This study compares the in vitro response and role of amino acid (AA) taste receptors (TASR) in the effect of AAs and a casein hydrolysate on ghrelin release and smooth muscle (SM) contractions in the proximal gut of lean and obese patients.

中文翻译:

肥胖会损害寡肽/氨基酸诱导的Ghrelin释放和人类近端胃中的平滑肌收缩

蛋白质的饱腹特性涉及对肠肽释放和胃肠蠕动的影响,这些作用可能在肥胖过程中发生改变。这项研究比较了氨基酸(AA)味觉受体(TASR)在AA和酪蛋白水解产物对瘦弱和肥胖患者近端肠中ghrelin释放和平滑肌(SM)收缩的影响中的体外反应和作用。
更新日期:2018-02-12
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