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High-throughput production of satellite-free droplets through a parallelized microfluidic deterministic lateral displacement device
Sensors and Actuators B: Chemical ( IF 8.0 ) Pub Date : 2018-01-11 , DOI: 10.1016/j.snb.2018.01.112
Naotomo Tottori , Takasi Nisisako

We present a parallel numbering-up device for microfluidic production of satellite droplet-free emulsions. The device consists of two stacked layers made of polydimethylsiloxane (PDMS). The bottom layer combines eight parallel sets of a microfluidic droplet generator (MFDG) and deterministic lateral displacement (DLD) array for size-based separation of main and satellite droplets. The top layer has input reservoirs to supply both the disperse and continuous phases evenly to the eight channels of the bottom layer. We employed 3D flow simulations to find the reservoirs most suitable for equal inflow distribution. Water-in-oil (W/O) droplets comprised of main droplets (∼67 μm in diameter) and satellite droplets (1–20 μm) were generated in the parallelized MFDGs, and they were then completely separated through the DLD arrays having a critical diameter of Dc = 37.1 μm. Thus, we confirmed production of satellite droplet-free emulsion droplets at 0.2 ml/h, eight times the processing throughput of single device (= 0.025 ml/h) without decrease in performance.



中文翻译:

通过平行微流确定性侧向位移装置高通量生产无卫星液滴

我们提出了一种用于微流体生产无卫星液滴乳液的并行编号装置。该设备由聚二甲基硅氧烷(PDMS)制成的两个堆叠层组成。底层结合了八组平行的微流液滴发生器(MFDG)和确定性横向位移(DLD)阵列,用于基于大小的主液滴和卫星液滴分离。顶层具有输入容器,可将分散相和连续相均匀地提供给底层的八个通道。我们采用3D流动模拟来找到最适合均流分布的储层。在平行化的MFDG中产生了由主液滴(直径约67μm)和附属液滴(1–20μm)组成的油包水(W / O)液滴,D c  =37.1μm。因此,我们证实了生产无卫星液滴的乳液液滴的速度为0.2 ml / h,是单个设备的处理通量(= 0.025 ml / h)的八倍,而性能并未下降。

更新日期:2018-01-11
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