The development of tissue-engineering (TE) solutions for osteochondral (OC) regeneration has been slowed by technical hurdles related to the recapitulation of their complex and hierarchical architecture. OC defects refer to damage of both the articular cartilage and the underlying subchondral bone. To repair an OC tissue defect, the complexity of the bone and cartilage must be considered. To help achieve this, microfluidics is converging with TE approaches to provide new treatment possibilities. Microfluidics uses precise micrometer-to-millimeter-scale fluid flows to achieve high-resolution and spatial and/or temporal control of the cell microenvironment, providing powerful tools for cell culturing. Herein, we overview the progress of microfluidics for developing 3D in vitro models of OC tissue, with a focus on cancer bone metastasis.

与复杂复杂的体系结构概述有关的技术障碍已减缓了用于骨软骨（OC）再生的组织工程（TE）解决方案的开发。OC缺损是指关节软骨和软骨下骨的损坏。要修复OC组织缺损，必须考虑骨骼和软骨的复杂性。为了帮助实现这一目标，微流体技术正在与TE方法融合，以提供新的治疗可能性。微流体技术使用精确的微米到毫米级的流体流来实现对细胞微环境的高分辨率和空间和/或时间控制，从而为细胞培养提供了强大的工具。在这里，我们概述了微流体在体外开发3D的进展。 组织模型，重点关注癌骨转移。