Modulation of endogenous adult stem cell niches represents a promising strategy for regeneration of tissues and to correct cell abnormalities, including cancer. Recent advances show the possibility to target endogenous stem cells or their progenies by using nanoparticles conjugated with specific biomolecules. In addition, the targeting of the stem cell niche can be accomplished by using stem cells loaded with nanoparticles. This review examines principles for the targeting of endogenous stem cells as well as factors for the modulation of stem cells.

中文翻译：

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干细胞作为载体和纳米颗粒的靶标

内源性成年干细胞壁的调节代表了一种有希望的组织再生和纠正包括癌症在内的细胞异常的策略。最近的进展表明，通过使用与特定生物分子结合的纳米颗粒，可以靶向内源性干细胞或其后代。另外，可以通过使用负载有纳米颗粒的干细胞来实现干细胞生态位的靶向。这篇综述探讨了靶向内源性干细胞的原理以及调节干细胞的因素。