Many studies suggested that polysaccharides could impact on the gut microbiota. To discover new polysaccharides which influence intestinal beneficial bacteria, a pectin polysaccharide FMP-6-S2 with an average molecular weight of 86.83 kDa was purified from Fructus Mori. The monosaccharide residue analysis indicated that FMP-6-S2 was composed of rhamnose, galacturonic acid, galactose and arabinose in a molar ratio of 30.86: 24.78: 28.70: 15.61. The backbone of FMP-6-S2 contained 1, 4-linked α-GalpA and 1, 2-linked α-Rhap with branches substituted at C-4 position of rhamnose. The branches were composed of 1, 4-linked β-Galp, terminal (T) − and 1, 3, 6-linked β-Galp, T- and 1, 5-linked α-Araf. Bioactivity test results suggested that FMP-6-S2 and its degraded product could promote growth of intestinal bacteria, B. thetaiotaomicron, which is a dominate strain in the gut of human to benefit intestinal mucosa. These results suggested that FMP-6-S2 and its degraded product might improve human wellness by modulating B. thetaiotaomicron.

许多研究表明，多糖可能会影响肠道菌群。发现哪些影响肠内有益菌新多糖，果胶多糖FMP-6-S2与86.83千道尔顿的平均分子量是从纯化桑椹。单糖残基分析表明FMP-6-S2由鼠李糖，半乳糖醛酸，半乳糖和阿拉伯糖组成，摩尔比为30.86：24.78：28.70：15.61。FMP-6-S2的主链含有1，1,4-连接的α-Gal的p A和1,2连接的α-鼠李p与分支在鼠李糖的C-4位取代。分支组成为：1，1,4-连接的β-gal p，终端（T） - 1，3，6-连接的β-Gal的p，T-和1,5连接的α-ara ˚F。生物活性测试结果表明，FMP-6-S2及其降解产物可促进肠道细菌B. thetaiotaomicron的生长，这是人类肠道中的主要菌株，可有益于肠道粘膜。这些结果表明，FMP-6-S2及其降解产物可能通过调节B. thetaiotaomicron改善人类健康。