The digestibility of fucosylated glycosaminoglycan (FG) and its effects on digestive enzymes were investigated using an in vitro digestion model. Results showed that the molecular weight and the reducing sugar content of FG were not significantly changed, and no free monosaccharides released from FG were detected after the salivary, gastric and intestinal digestion, indicating that both the backbone and the sulfated fucose branches of FG are resistant to be cleaved in the saliva and gastrointestinal tract environments. Furthermore, FG can dose-dependently inhibit digestive enzymes such as α-amylase, pepsin and pancreatic lipase in different degrees under the simulated digestion conditions due to the sulfate and carboxyl groups. These physiological effects of FG may help control the postprandial glucose concentration and have the potential in the prevention or treatment of reflux disease and obesity. The findings may provide information on the digestibility and beneficial physiological effects of FG as a potential natural product to promote human health.

使用体外消化模型研究了岩藻糖基化糖胺聚糖（FG）的可消化性及其对消化酶的影响。结果表明，唾液，胃和肠消化后，FG的分子量和还原糖含量没有明显变化，并且未检测到FG释放的游离单糖，表明FG的骨架和硫酸盐岩藻糖分支均具有抗性在唾液和胃肠道环境中裂解。此外，由于硫酸盐和羧基，在模拟的消化条件下，FG可以不同程度地剂量依赖性地抑制消化酶，例如α-淀粉酶，胃蛋白酶和胰脂肪酶。FG的这些生理作用可能有助于控制餐后血糖浓度，并具有预防或治疗反流疾病和肥胖症的潜力。这些发现可能提供有关FG的消化率和有益生理作用的信息，FG是促进人类健康的潜在天然产物。