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A New Co‐P Nanocomposite with Ultrahigh Relaxivity for In Vivo Magnetic Resonance Imaging‐Guided Tumor Eradication by Chemo/Photothermal Synergistic Therapy
Small ( IF 13.0 ) Pub Date : 2018-01-11 , DOI: 10.1002/smll.201702431 Jianhua Liu 1, 2, 3 , Longhai Jin 2 , Yinghui Wang 1 , Xing Ding 1, 3 , Songtao Zhang 1 , Shuyan Song 1 , Daguang Wang 4 , Hongjie Zhang 1
Small ( IF 13.0 ) Pub Date : 2018-01-11 , DOI: 10.1002/smll.201702431 Jianhua Liu 1, 2, 3 , Longhai Jin 2 , Yinghui Wang 1 , Xing Ding 1, 3 , Songtao Zhang 1 , Shuyan Song 1 , Daguang Wang 4 , Hongjie Zhang 1
Affiliation
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Design of new nanoagents that intrinsically have both diagnostic imaging and therapeutic capabilities is highly desirable for personalized medicine. In this work, a novel nanotheranostic agent is fabricated based on polydopamine (PDA)‐functionalized Co‐P nanocomposites (Co‐P@PDA) for magnetic resonance imaging (MRI)‐guided combined photothermal therapy and chemotherapy. The ultrahigh relaxivity of 224.61 mm−1 s−1 can enable Co‐P@PDA to be applied as an excellent contrast agent for MRI in vitro and in vivo, providing essential and comprehensive information for tumor clinical diagnosis. Moreover, Co‐P@PDA exhibit excellent photothermal performance owing to the strong near‐infrared (NIR) absorbance of both Co‐P nanocomposite and PDA. Highly effective ablation of tumors is achieved in a murine tumor model because the NIR laser not only induces photothermal effects but also triggers the chemotherapeutic drug on‐demand release, which endows the Co‐P@PDA with high curative effects but little toxicity and few side effects. These findings demonstrate that Co‐P@PDA are promising agents for highly effective and precise antitumor treatment and warrant exploration as novel theranostic nanoagents with good potential for future clinical translation.
中文翻译：
一种新的具有超高弛豫度的Co-P纳米复合材料，用于化学/光热协同疗法消除体内磁共振成像引导的肿瘤
对于个性化医学来说，设计本质上具有诊断成像和治疗功能的新型纳米试剂是非常必要的。在这项工作中，基于聚多巴胺（PDA）功能化的Co-P纳米复合材料（Co-P @ PDA）制备了一种新型的纳米热能剂，用于磁共振成像（MRI）引导的光热疗法和化学疗法的联合治疗。224.61 m m -1 s -1的超高松弛度可以使Co-P @ PDA用作体外和体内MRI的出色造影剂，从而为肿瘤临床诊断提供必要而全面的信息。此外，由于Co-P纳米复合材料和PDA均具有很强的近红外（NIR）吸收能力，因此Co-P @ PDA表现出出色的光热性能。在鼠肿瘤模型中实现了高效消融，因为近红外激光不仅诱导光热效应，而且还触发了化学治疗药物的按需释放，这赋予了Co-P @ PDA较高的治疗效果，但毒性小且副作用少效果。这些发现表明，Co-P @ PDA是用于高效且精确的抗肿瘤治疗的有前途的药物，值得探索，因为它们是新型的治疗性纳米药物，具有未来临床翻译的良好潜力。
更新日期：2018-01-11
中文翻译：
一种新的具有超高弛豫度的Co-P纳米复合材料，用于化学/光热协同疗法消除体内磁共振成像引导的肿瘤
对于个性化医学来说，设计本质上具有诊断成像和治疗功能的新型纳米试剂是非常必要的。在这项工作中，基于聚多巴胺（PDA）功能化的Co-P纳米复合材料（Co-P @ PDA）制备了一种新型的纳米热能剂，用于磁共振成像（MRI）引导的光热疗法和化学疗法的联合治疗。224.61 m m -1 s -1的超高松弛度可以使Co-P @ PDA用作体外和体内MRI的出色造影剂，从而为肿瘤临床诊断提供必要而全面的信息。此外，由于Co-P纳米复合材料和PDA均具有很强的近红外（NIR）吸收能力，因此Co-P @ PDA表现出出色的光热性能。在鼠肿瘤模型中实现了高效消融，因为近红外激光不仅诱导光热效应，而且还触发了化学治疗药物的按需释放，这赋予了Co-P @ PDA较高的治疗效果，但毒性小且副作用少效果。这些发现表明，Co-P @ PDA是用于高效且精确的抗肿瘤治疗的有前途的药物，值得探索，因为它们是新型的治疗性纳米药物，具有未来临床翻译的良好潜力。
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