Findings from Francis Chan and colleagues' study (June 17, 2017, p 2375)¹ showed a 6·7% absolute risk reduction in recurrent upper gastrointestinal bleeding with celecoxib plus esomeprazole compared with naproxen and esomeprazole in patients who were on non-steroidal anti-inflammatory drugs and receiving concomitant aspirin following an upper gastrointestinal bleed. Additionally, the authors reported no significant difference between groups in serious cardiovascular events (4·4% [95% CI 2·4–7·7] for patients given celecoxib plus esomeprazole vs 5·5% [3·3–9·2] for those given naproxen plus esomeprazole; p=0·543), although their study was not adequately powered to evaluate this secondary outcome.

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有关CONCERN审判的问题

Francis Chan及其同事的研究结果（2017年6月17日，第2375页）¹显示，接受非甾体类抗抑郁药的患者与萘普生和依索美拉唑相比，塞来昔布加依索美拉唑的复发性上消化道出血绝对风险降低6·7％ -炎症药物并在上消化道出血后接受阿司匹林治疗。此外，作者报告说两组之间在严重心血管事件方面无显着差异（使用塞来昔布加埃索美拉唑的患者为4·4％[95％CI 2·4-7·7]与5·5％[3·3-9·2]对于接受萘普生加埃索美拉唑治疗的患者； p = 0·543），尽管他们的研究不足以评估该次要结局。