The present study demonstrated the binary and ternary complexes of Zaltoprofen (ZPF) with β-CD and HP-β-CD. The products were characterized using solubility, in vitro dissolution, DSC, and PXRD studies. The mode of interaction of guest and host was revealed through ¹H NMR and FT-IR studies. A significant increase was noticed in the stability constant (K_c) and complexation efficiency (CE) of β-CD and HP-β-CD due to addition of L-Arg in ternary complexes. The ternary complexes showed a greater increase in solubility and dissolution of ZPF than binary complexes. Thus, ternary system of ZPF could be an innovative approach for its solubility and dissolution enhancement.

本研究证明了扎托洛芬（ZPF）与β-CD和HP-β-CD的二元和三元复合物。使用溶解度，体外溶解，DSC和PXRD研究对产品进行表征。通过¹ H NMR和FT-IR研究揭示了来宾与宿主的相互作用方式。由于在三元复合物中添加了L-Arg，β-CD和HP-β-CD的稳定性常数（K _c）和络合效率（CE）显着增加。三元配合物显示出ZPF的溶解度和溶解度比二元配合物更大。因此，ZPF的三元体系可能是其溶解度和溶解度提高的创新方法。