A highly efficient copper‐catalyzed C−H/N−H cross dehydrogenative coupling between picolinamides and simple ethers was developed. The reaction was promoted by the chelation assistance of removable picolinyl group and exhibited excellent TON and TOF number. This method was applicable to both N‐aryl and alkyl picolinamides as well as various cyclic and acyclic ethers with good functional group compatibility. It also possessed the merit of air and moisture tolerance and easy operation.

中文翻译：

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铜催化下吡啶甲酰胺与简单醚之间螯合促进的高效C / H / N-H交叉脱氢偶联

在吡啶甲酰胺和简单醚之间开发了一种高效的铜催化CH / NH交叉脱氢偶联剂。可移动的吡啶基的螯合辅助促进了反应，并显示出优异的TON和TOF值。该方法适用于N-芳基和烷基吡啶甲基酰胺以及具有良好官能团相容性的各种环状和无环醚。它还具有耐空气和潮湿的优点，并且易于操作。