Interfacing biomolecules with functional materials is a key strategy toward achieving externally‐triggered biological function. The rational integration of functional proteins, such as enzymes, with plasmonic nanostructures that exhibit unique optical properties such as photothermal effect provides a means to externally control the enzyme activity. However, due to the labile nature of enzymes, the photothermal effect of plasmonic nanostructures is mostly utilized for the enhancement of the biocatalytic activity of thermophilic enzymes. In order to extend and utilize the photothermal effect to a broader class of enzymes, a means to stabilize the immobilized active protein is essential. Inspired by biomineralization for the encapsulation of soft tissue within protective exteriors in nature, metal–organic framework is utilized to stabilize the enzyme. This strategy provides an effective route to enhance and externally modulate the biocatalytic activity of enzymes bound to functional nanostructures over a broad range of operating environments that are otherwise hostile to the biomolecules.

中文翻译：

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金属有机骨架封装，用于酶活性的保存和光热增强

生物分子与功能材料的连接是实现外部触发的生物功能的关键策略。功能蛋白（例如酶）与具有独特光学性质（例如光热效应）的等离激元纳米结构的合理整合提供了一种从外部控制酶活性的方法。然而，由于酶的不稳定性质，等离子纳米结构的光热效应主要用于增强嗜热酶的生物催化活性。为了将光热效应扩展和利用到更广泛的酶类别，稳定固定化的活性蛋白的方法是必不可少的。受生物矿化作用的启发，将金属组织封装在自然界的保护性外部环境中，利用金属有机框架来稳定酶。