Seven rare pyrrospirones C−I (1–7) as well as 18 known compounds were isolated from a marine-derived fungus Penicillium sp. ZZ380. Structures of the new pyrrospirones were elucidated by extensive NMR spectroscopic analyses, HRESIMS data, and Mosher's method. Pyrrospirone D (2) was also confirmed by X-ray diffraction analysis. Pyrrospirone G (5) showed potent activity in inhibiting the proliferation of different glioma cells with IC₅₀ values of 1.06–8.52 μM and pyrrospirones C (1), F (4), and I (7) had antimicrobial activity against the growth of both methicillin-resistant Staphylococcus aureus and Escherichia coli with MIC values of 2.0–5.0 μg/mL.

从海生真菌青霉菌中分离出七种稀有吡咯烷酮C- 1（1-7）以及18种已知化合物。ZZ380。通过广泛的NMR光谱分析，HRESIMS数据和Mosher方法，阐明了新型吡咯烷酮的结构。还通过X射线衍射分析确认了吡咯螺酮D（2）。吡咯烷酮G（5）在抑制不同神经胶质瘤细胞的增殖方面表现出强大的活性，IC ₅₀值为1.06-8.52μM，吡咯烷酮C（1），F（4）和I（7）对两者的生长均具有抗菌活性耐甲氧西林金黄色葡萄球菌和大肠杆菌与2.0-5.0微克/毫升的MIC值。