A glycosyl dithiocarbamate derivative is developed as a “turn on” fluorescent sensor for lectins. The probe is prepared through a three‐component reaction in good yield and fully characterized by analytical experiments. Upon interaction with lectin ConA, the virtually non‐fluorescent probe has shown “turn on” sensing with absolute specificity in terms of the carbohydrate used, mannose in this particular case. The probe with galactose remained inactive with ConA. The simple and general strategy for the synthesis of this particular probe offers the scope for multiple probes by altering the carbohydrate moiety and thus, opens up the avenue to target various lectin sensing.

中文翻译：

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糖基二硫代氨基甲酸酯的使用：碳水化合物结合蛋白的小分子“打开”荧光探针

糖基二硫代氨基甲酸酯衍生物被开发为凝集素的“开启”荧光传感器。通过三组分反应以高收率制备探针，并通过分析实验对其进行了全面表征。与凝集素ConA相互作用后，实际上无荧光的探针显示出“开启”感测，就所用的碳水化合物（在这种情况下为甘露糖）而言，具有绝对的特异性。带有半乳糖的探针对ConA保持非活性。用于合成该特定探针的简单且通用的策略通过改变碳水化合物部分为多种探针提供了范围，因此开辟了靶向各种凝集素感测的途径。