Derivatives of multisubstituted unnatural prolines show catalytic reactivities different from those of the natural amino acid and indicate a high potential for new organic reaction sequences. Recent work published in Angewandte Chemie by Cossío and co-workers reports a novel asymmetric organocatalytic domino reaction employing a catalytic system based on multisubstituted unnatural prolines.

中文翻译：

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不对称催化多米诺反应的多取代非天然脯氨酸

多取代的非天然脯氨酸的衍生物显示出与天然氨基酸不同的催化反应性，并显示出新的有机反应序列的高潜力。Cossío及其同事在Angewandte Chemie上发表的最新工作报道了一种新颖的不对称有机催化多米诺反应，该反应采用了基于多取代非天然脯氨酸的催化体系。