Transcatheter arterial embolization of aneurysm with metal microcoils is notoriously prone to recanalization arising from the low filling ratio due to their extreme rigidity. Smart hydrogel microcoils with tunable modulus may essentially significantly improve the therapeutic efficacy. Here, a radiopaque highly stiff body‐temperature‐triggered shape memory (SM) hydrogel is fabricated for the first time by introducing reversible hydrophobic dipole pairing microdomains in the flexibly crosslinked network, followed by BaSO₄ precipitation. This radiopacification does not affect their mechanical performances as well as the SM effect. It is demonstrated that the mechanical properties of SM hydrogels are comparable to those of rubbers and can be modulated by adjusting temperature ranging from 20 to 40 °C. Benefiting from the thermoresponsive mechanical properties, the stiff radiopaque hydrogel strip can easily pass through a catheter under the protection of cool saline for delivery into pig's renal artery, and spontaneously and rapidly transformed into a microcoil upon contacting blood. Real‐time angiogram reveals that continuous delivery of several hydrogel microcoils can efficiently occlude the blood supply. The kidneys are atrophied considerably over three month postoperative follow‐up, and no recanalization occurs throughout the experimental time. These novel hydrogel microcoils are promising to be developed as novel permanent embolic agents for treating aneurysm.

中文翻译：

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永久性动脉栓塞的不透射线的高刚度和韧性的形状记忆水凝胶微线圈

众所周知，金属微线圈对动脉导管的动脉栓塞术由于其极高的刚性而导致的低充盈率而导致易于再通。具有可调模量的智能水凝胶微线圈可从实质上显着改善治疗效果。在这里，通过在柔性交联网络中引入可逆疏水偶极对微区，然后是BaSO ₄，首次制造了不透射线的高刚性体温触发形状记忆（SM）水凝胶。沉淀。这种射线不透不会影响其机械性能以及SM效果。结果表明，SM水凝胶的机械性能与橡胶相当，可以通过调节20至40°C的温度来调节。得益于热响应机械性能，坚硬的不透射线水凝胶条可在冷盐水的保护下轻松通过导管，以输送到猪的肾动脉中，并在与血液接触后自发迅速转变成微线圈。实时血管造影显示，连续输送几个水凝胶微线圈可以有效地阻塞血液供应。在术后三个月的随访中，肾脏明显萎缩，并且在整个实验过程中均未发生再通。