Nanostructured Lipid‐Based Films for Substrate‐Mediated Applications in Biotechnology,Advanced Functional Materials

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Nanostructured Lipid‐Based Films for Substrate‐Mediated Applications in Biotechnology
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2018-01-10 , DOI: 10.1002/adfm.201704356
Minjee Kang ₁ , Mohit Tuteja _{2,

3} , Andrea Centrone ₂ , Daniel Topgaard ₄ , Cecilia Leal ₁

Affiliation

Amphiphilic in nature, lipids spontaneously self‐assemble into a range of nanostructures in the presence of water. Among lipid self‐assembled structures, liposomes and supported lipid bilayers have long held scientific interest for their main applications in drug delivery and plasma membrane models, respectively. In contrast, lipid‐based multilayered membranes on solid supports only recently begin drawing scientists' attention. Current studies show that the stacking of multiple bilayers on a solid support yields cooperative structural and dynamic behavior that enables new functionalities. Lipid films provide compartmentalization, templating, and enhanced release of molecules of interest. Importantly, supported lipid phases exhibit long‐range periodic nanoscale order and orientation that is tunable in response to a changing environment. Herein, the current understanding of lipid‐based film research is summarized focusing on how unique structural characteristics enable the emergence of new applications including label‐free biosensors, macroscale drug delivery, and substrate‐mediated gene delivery. The authors' recent contributions focusing on the structural characterization of lipid‐based films using small‐angle X‐ray scattering and atomic force microscopy are highlighted. In addition, new photothermally induced resonance and solid‐state nuclear magnetic resonance data are described, providing insights into drug partition in lipid‐based films as well as structure and dynamics at the molecular scale.

中文翻译：

用于生物技术中基质介导应用的纳米结构脂质基薄膜

脂质本质上是两亲性的，在水存在下会自发地自组装成一系列纳米结构。在脂质自组装结构中，脂质体和支持的脂质双层分别因其在药物输送和质膜模型中的主要应用而长期以来一直受到科学界的关注。相比之下，固体支持物上的基于脂质的多层膜最近才开始引起科学家的注意。目前的研究表明，在固体支撑物上堆叠多个双层会产生协作的结构和动态行为，从而实现新的功能。脂质膜提供区室化、模板化和增强感兴趣分子的释放。重要的是，支持的脂质相表现出长范围的周期性纳米级有序和方向，可以根据不断变化的环境进行调整。在此，总结了目前对脂质膜研究的理解，重点关注独特的结构特征如何促进新应用的出现，包括无标记生物传感器、大规模药物递送和底物介导的基因递送。重点介绍了作者最近的贡献，重点是使用小角 X 射线散射和原子力显微镜来表征脂质薄膜的结构。此外，还描述了新的光热诱导共振和固态核磁共振数据，为了解脂质薄膜中的药物分配以及分子尺度的结构和动力学提供了见解。

更新日期：2018-01-10

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