The synthesis of pyrazole triflones containing a triflyl group at the 3-position is disclosed. Treatment of 2-diazo-1-phenyl-2-((trifluoromethyl)sulfonyl)ethan-1-one with nitroalkenes under basic conditions gave pharmaceutically attractive pyrazole 3-triflones in good to high yields. The generation of anionic triflyldiazomethane species followed by the [3 + 2] cycloaddition reaction with nitroalkenes is proposed for this transformation. 3-(Difluoromethanesulfonyl)pyrazoles were also synthesized by using a previously unknown anionic (difluoromethanesulfonyl)diazomethane species under a similar strategy.

中文翻译：

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阴离子三重氮唑甲烷：通过[3 + 2]环加成反应生成吡咯-3-三氟甲磺酸酯及其应用

公开了在3-位上含有三氟甲基的吡唑三氟酮的合成。在碱性条件下用硝基烯烃处理2-重氮-1-苯基-2-（（三氟甲基）磺酰基）乙-1-酮，以良好或高收率得到了药学上有吸引力的吡唑3-三氟甲磺酸酯。对于该转化，提出了生成阴离子三重氮重氮甲烷物质，然后与硝基烯烃进行[3 + 2]环加成反应。还通过在类似策略下使用先前未知的阴离子（二氟甲磺酰基）重氮甲烷物质合成了3-（二氟甲磺酰基）吡唑。