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The impact of development of atherosclerosis on delamination resistance of the thoracic aortic wall
Journal of the Mechanical Behavior of Biomedical Materials ( IF 3.3 ) Pub Date : 2018-01-11 , DOI: 10.1016/j.jmbbm.2018.01.009
Marta Kozuń , Magdalena Kobielarz , Agnieszka Chwiłkowska , Celina Pezowicz

The aim of this work is to determine the impact of development of atherosclerosis on dissection of the human thoracic aorta on the basis of an analysis of the mechanical properties of the interfaces between its layers.

The research material consisted of 17 pathologically unchanged aortae and 74 blood vessels with atherosclerotic lesions, which were classified according to the histological classification by Stary. The subject of the analysis were the interfaces between the adventitia and the media-intima complex (A-MIC) and between the intima and the media-adventitia complex (I-MAC). The mechanical properties of the above interfaces were determined by the peeling test in the longitudinal and circumferential directions.

The results indicate that development of atherosclerosis reduces vessel wall resistance to delamination. The greatest risk of dissection occurs at stage IV of the disease. In this case, energy values are lower by about 28% for the I-MAC interface and by 39% for the A-MIC interface compared with normal tissues. Lower values of mean force and energy were obtained for the I-MAC interface, indicating that this interface is more susceptible to delamination. The mechanical properties of the A-MIC interfaces are directional.



中文翻译:

动脉粥样硬化的发展对胸主动脉壁脱层阻力的影响

这项工作的目的是在分析其各层之间界面的机械特性的基础上,确定动脉粥样硬化的发展对人胸主动脉解剖的影响。

研究材料由17个病理上不变的主动脉和74个具有动脉粥样硬化病变的血管组成,并根据Stary的组织学分类对其进行了分类。分析的主题是外膜和中膜-内膜复合物(A-MIC)之间以及内膜和中膜-外膜复合物(I-MAC)之间的界面。上述界面的机械性能通过在纵向和圆周方向上的剥离测试来确定。

结果表明,动脉粥样硬化的发展降低了血管壁对分层的抵抗力。解剖的最大风险发生在该疾病的IV期。在这种情况下,与正常组织相比,I-MAC接口的能量值降低了约28%,而A-MIC接口的能量值降低了39%。I-MAC界面的平均力和能量值较低,表明该界面更容易分层。A-MIC接口的机械性能是定向的。

更新日期:2018-01-11
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