We appreciate the additional data regarding calprotectin and radiographic progression provided by Chevreau et al 1 as an eLetter addressing our published research paper.2 It is important to explore new biomarkers in different cohorts of patients with early and established rheumatoid arthritis (RA). Calprotectin levels have previously been shown to be associated with joint damage in established RA.3 4 Hammer et al 5 have shown that calprotectin was an independent predictor of radiographic joint damage after 10 years of follow-up. Chevreau et al present data on baseline calprotectin as a predictor of rapid radiographic progression (defined as an increase of ≥5 van der Heijde Sharp score units/year) in a large cohort of patients with early RA, and did not find calprotectin to be associated with structural damage when baseline erosions were …

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回应：Chevreauet al 的“钙卫蛋白在预测早期类风湿性关节炎的放射学进展方面并非独立于基线侵蚀”

我们感谢 Chevreau 等人 1 作为针对我们已发表研究论文的电子信件提供的关于钙卫蛋白和放射学进展的额外数据。2 在早期和已确诊的类风湿性关节炎 (RA) 患者的不同队列中探索新的生物标志物非常重要。先前已证明钙卫蛋白水平与已确定的 RA 中的关节损伤有关。3 4 Hammer 等人 5 表明，在 10 年的随访后，钙卫蛋白是放射学关节损伤的独立预测因子。Chevreau 等人在一大群早期 RA 患者中提供了基线钙卫蛋白作为快速放射学进展（定义为增加≥5 van der Heijde Sharp 评分单位/年）的预测因子的数据，并且没有发现钙卫蛋白与此相关当基线侵蚀是……