We have read with great interest the article by Jonsson et al that was recently published online in ARD ,1 which suggested that calprotectin, also known as S100A8/S100A9 heterodimer, was associated with radiographic progression in early rheumatoid arthritis (RA). Calprotectin correlates significantly with inflammatory markers and disease activity score.2 Besides correlations between baseline calprotectin levels, Clinical Disease Activity Index and ultrasonography power Doppler, the authors showed that baseline calprotectin levels correlated with van der Heijde modified Sharp score (SHS) progression (defined as an increase ≥1 unit/year from 0 to 24 months), independently of age, gender, Clinical Disease Activity Index, erythrocyte sedimentation rate (ESR), C reactive protein (CRP) levels and rheumatoid factor positivity.1 We analysed the initial serum calprotectin among patients with early RA fulfilling American College of Rheumatology/European League Against Rheumatism 2010 of the French observational cohort Etude et Suivi des POlyarthrites Indifferenciees Recentes (ESPOIR). Calprotectin serum concentrations were assessed according to manufacturer method (Hycult, Frontstraat, Netherlands; …

中文翻译：

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钙卫蛋白在预测早期类风湿性关节炎的放射学进展方面并非独立于基线侵蚀。Jonssonet al 对“钙卫蛋白作为早期类风湿性关节炎患者炎症标志物”的评论

我们非常感兴趣地阅读了 Jonsson 等人最近在 ARD 上发表的文章1，该文章表明钙卫蛋白，也称为 S100A8/S100A9 异二聚体，与早期类风湿性关节炎 (RA) 的放射学进展有关。钙卫蛋白与炎症标志物和疾病活动评分显着相关。2 除了基线钙卫蛋白水平、临床疾病活动指数和超声能量多普勒之间的相关性之外，作者表明基线钙卫蛋白水平与范德海德修正夏普评分 (SHS) 进展（定义为从 0 到 24 个月增加≥1 单位/年），与年龄、性别、临床疾病活动指数、红细胞沉降率 (ESR)、C 反应蛋白 (CRP) 水平和类风湿因子阳性无关。1 我们分析了法国观察队列 Etude et Suivi des POlyarthrites Indiferenciees Neares (ESPOIR) 的美国风湿病学会/欧洲抗风湿病联盟 2010 的早期 RA 患者的初始血清钙卫蛋白。根据制造商的方法（Hycult，Frontstraat，荷兰；……