Injectable hydrogels have been an attractive topic in biomaterials. However, during gelation in vivo, they are easy to disperse due to tissue exudates, thus leading to failure of controlled drug release. To solve this problem, we present a novel polysaccharide-based injectable hydrogel via self-crosslinking of aldehyde-modified xanthan (Xan-CHO) and carboxymethyl-modified chitosan (NOCC). The physical properties were optimized by adjusting the mass ratio of Xan-CHO and NOCC. Experiments revealed that this material exhibited the characteristics of self-healing, anti-enzymatic hydrolysis, biocompatibility and biodegradability. The releasing curve demonstrated stable release of BSA-FITC within 10 hours after injection in liquids. After incorporation with a vascular endothelial growth factor, there was an interaction between this biomaterial and the host, which accelerated the reconstruction of the abdominal wall in rats. Therefore, this injectable hydrogel, as a drug delivery system, can prevent drug outburst in a variety of settings and function as a tissue scaffold.

可注射的水凝胶一直是生物材料中的一个有吸引力的话题。但是，在体内凝胶化过程中，由于组织渗出物，它们易于分散，从而导致药物释放受控失败。为了解决这个问题，我们提出了一种新型的基于多糖的可注射水凝胶，它是通过醛改性的黄原胶（Xan-CHO）和羧甲基改性的壳聚糖（NOCC）的自交联而形成的。通过调节Xan-CHO和NOCC的质量比来优化物理性能。实验表明，该材料具有自我修复，抗酶水解，生物相容性和生物降解性的特点。释放曲线表明，注入液体后10小时内BSA-FITC稳定释放。掺入血管内皮生长因子后，这种生物材料与宿主之间存在相互作用，从而加速了大鼠腹壁的重建。因此，这种可注射的水凝胶作为药物输送系统，可以在各种情况下防止药物爆发，并起组织支架的作用。