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Transiently malleable multi-healable hydrogel nanocomposites based on responsive boronic acid copolymers†
Polymer Chemistry ( IF 4.1 ) Pub Date : 2018-01-10 00:00:00 , DOI: 10.1039/c7py01202k Adérito J. R. Amaral 1, 2, 3, 4 , Mina Emamzadeh 1, 2, 3, 4 , George Pasparakis 1, 2, 3, 4
Polymer Chemistry ( IF 4.1 ) Pub Date : 2018-01-10 00:00:00 , DOI: 10.1039/c7py01202k Adérito J. R. Amaral 1, 2, 3, 4 , Mina Emamzadeh 1, 2, 3, 4 , George Pasparakis 1, 2, 3, 4
Affiliation
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The design of materials that mimic aspects of self-healing, as observed in nature, is of paramount importance as they could solve a number of problems in the biomedical field, such as the elimination of (bio-)material failure after prolonged use, improved integration at the interface with living tissues and more robust biomechanical performance. In this report, we propose the fabrication of soft hydrogels comprising a polymer matrix of poly(vinyl alcohol) mixed with a thermoresponsive boronic acid copolymer that is subsequently impregnated with poly(vinyl pyrrolidone) coated gold nanoparticles. The gels are crosslinked by the formation of reversible boronate ester bonds that can be remotely disrupted by a thermal or optical stimulus, endowing the gels with thermally-induced transient malleability that is optically trackable. It is demonstrated that the gels exhibit excellent healing properties within minutes even without the application of external stimuli. The rapid formation of the gels in concert with their fast and mild gel–sol phase transition under biologically relevant conditions is demonstrated by the encapsulation and release of cells in vitro. The proposed materials constitute a versatile cytocompatible platform for the construction of remotely healable soft gels for biomedical applications.
中文翻译：
基于响应性硼酸共聚物的瞬态可延展的多愈合水凝胶纳米复合材料†
自然界中观察到的模仿自我修复方面的材料的设计至关重要，因为它们可以解决生物医学领域的许多问题，例如消除长期使用后消除的（生物）材料失效，改进在与活组织的界面处整合，并具有更强大的生物力学性能。在这份报告中，我们提出了一种软水凝胶的制造方法，该软水凝胶包括与热响应性硼酸共聚物混合的聚乙烯醇聚合物基体，然后将其浸渍有聚乙烯基吡咯烷酮涂层的金纳米颗粒。凝胶通过形成可逆的硼酸酯键而交联，该可逆的硼酸酯键可被热或光学刺激远程破坏，使凝胶具有可光学追踪的热诱导的瞬时可延展性。证明了即使在没有施加外部刺激的情况下，该凝胶在数分钟内仍表现出优异的愈合性能。在生物相关条件下，凝胶的快速形成与其快速和温和的凝胶-溶胶相变相一致，这通过细胞的包封和释放得以证明。体外。所提出的材料构成了通用的细胞相容性平台，用于构建用于生物医学应用的可远距离修复的软凝胶。
更新日期：2018-01-10
中文翻译：
基于响应性硼酸共聚物的瞬态可延展的多愈合水凝胶纳米复合材料†
自然界中观察到的模仿自我修复方面的材料的设计至关重要，因为它们可以解决生物医学领域的许多问题，例如消除长期使用后消除的（生物）材料失效，改进在与活组织的界面处整合，并具有更强大的生物力学性能。在这份报告中，我们提出了一种软水凝胶的制造方法，该软水凝胶包括与热响应性硼酸共聚物混合的聚乙烯醇聚合物基体，然后将其浸渍有聚乙烯基吡咯烷酮涂层的金纳米颗粒。凝胶通过形成可逆的硼酸酯键而交联，该可逆的硼酸酯键可被热或光学刺激远程破坏，使凝胶具有可光学追踪的热诱导的瞬时可延展性。证明了即使在没有施加外部刺激的情况下，该凝胶在数分钟内仍表现出优异的愈合性能。在生物相关条件下，凝胶的快速形成与其快速和温和的凝胶-溶胶相变相一致，这通过细胞的包封和释放得以证明。体外。所提出的材料构成了通用的细胞相容性平台，用于构建用于生物医学应用的可远距离修复的软凝胶。
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