Albusnodin: an acetylated lasso peptide from Streptomyces albus,Chemical Communications

当前位置： X-MOL 学术 › Chem. Commun. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Albusnodin: an acetylated lasso peptide from Streptomyces albus
Chemical Communications ( IF 4.3 ) Pub Date : 2018-01-10 00:00:00 , DOI: 10.1039/c7cc08620b
Chuhan Zong _{1,

2,

3,

4} , Wai Ling Cheung-Lee _{2,

3,

4,

5} , Hader E. Elashal _{1,

4,

6,

7} , Monika Raj _{1,

4,

6,

7} , A. James Link _{2,

3,

4,

5,

8}

Affiliation

We describe a lasso peptide, albusnodin, that is post-translationally modified with an acetyl group, the first example of a lasso peptide with this modification. Using heterologous expression, we further show that the acetyltransferase colocalized with the albusnodin gene cluster is required for the biosynthesis of this lasso peptide. This type of lasso peptide is widespread in Actinobacteria with 44 examples found in currently sequenced genomes.

中文翻译：

Albusnodin：来自白色链霉菌的乙酰化套索肽

我们描述了一个套索肽，albusnodin，它是用乙酰基翻译后修饰的，是具有这种修饰的套索肽的第一个例子。使用异源表达，我们进一步表明，与套索蛋白基因簇共定位的乙酰基转移酶是该套索肽的生物合成所必需的。这种类型的套索肽在放线菌中很普遍，在当前测序的基因组中发现了44个实例。

更新日期：2018-02-02

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11