AbstractA cellulose paper was modified with an aptamer against methamphetamine on either carbon dots (CDs) or on multichannel carbon nanotubes (CNTs). The resulting sorbent was applied to the extraction of METH from blood or saliva. The METH-loaded paper than also was directly applied as a paper spray ionization source in ion mobility spectrometry. The carbon nanomaterial enhances sensitivity, and the aptamer enhances selectivity. The materials were covalently bound to the paper on one side, while the aptamer was immobilized on the other. After optimization of the extraction process and instrumental parameters, the limits of detection when using the aptamer-CNT modified paper are 0.6 ng·mL−1 for saliva, and 0.45 ng·mL−1 for plasma. The respective values when using aptamer-CD modified paper are 1.5 ng·mL−1 for saliva and 0.9 ng·mL−1 for plasma. Calibration plots are linear in the 2 to 150 ng·mL−1 METH concentration range for saliva, and in the 1.5 to 200 ng·mL−1 concentration ranges for blood when using the aptamer-CNT based method. When using the aptamer-CDs, the dynamic ranges extend from 5 to 200 ng·mL−1 and from 3 to 250 ng·mL−1, respectively. The method was applied to the determination of METH in real samples of saliva and blood, and the accuracy of the method was confirmed by comparison of the results with data analyzed by GC-MS. Graphical abstractᅟ

中文翻译：

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基于适配体修饰的碳纳米材料的吸附与纸喷雾离子迁移谱耦合，用于甲基苯丙胺的高灵敏度和选择性测定

摘要在碳点 (CD) 或多通道碳纳米管 (CNT) 上用抗甲基苯丙胺的适体对纤维素纸进行了修饰。所得吸附剂用于从血液或唾液中提取 METH。载有 METH 的纸也直接用作离子迁移谱中的纸喷雾电离源。碳纳米材料提高灵敏度，适体提高选择性。材料的一侧共价结合到纸上，而适体固定在另一侧。优化提取工艺和仪器参数后，使用aptamer-CNT改性纸的检测限为唾液0.6 ng·mL-1，血浆0.45 ng·mL-1。使用aptamer-CD 修饰纸时，唾液分别为1.5 ng·mL-1，血浆为0.9 ng·mL-1。当使用基于适配体-CNT 的方法时，校准图在唾液的 2 至 150 ng·mL-1 METH 浓度范围内和血液的 1.5 至 200 ng·mL-1 浓度范围内呈线性。当使用适体-CD 时，动态范围分别从 5 到 200 ng·mL-1 和从 3 到 250 ng·mL-1。将该方法应用于唾液和血液实际样品中METH的测定，结果与GC-MS分析数据的比较验证了该方法的准确性。图形摘要ᅟ 将该方法应用于唾液和血液实际样品中METH的测定，结果与GC-MS分析数据的比较验证了该方法的准确性。图形摘要ᅟ 将该方法应用于唾液和血液实际样品中METH的测定，结果与GC-MS分析数据的比较验证了该方法的准确性。图形摘要ᅟ