New insights into the design of highly sensitive, carbon‐based electrochemical sensors are presented in this work. This was achieved by exploring the interesting properties of conductive (Mg/Al) layered double hydroxide‐dodecyl sulphate/polypyrrole nanocomposites which were synthesized by in‐situ polymerization of pyrrole during the assembly of (Mg/Al) layered double hydroxide, and by employing the anionic surfactant dodecyl sulphate as a modifier. Changes in morphology and surface area of the nanocomposites occured as a result of change in pyrrole percentage. Under optimal conditions, the modified carbon paste electrode successfully achieved detection limits of 0.057 and 0.134 nmol L⁻¹ of Terazosin hydrochloride in pharmaceutical formulation and spiked human serum fluid, respectively. Moreover, the sensors are highly stable, reusable and free of interference by other commonly present excipients in drug formulations.

中文翻译：

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基于层状双氢氧化物/聚吡咯/碳糊的电化学传感器的制备，用于测定α-肾上腺素能阻断剂特拉唑嗪

这项工作提出了对高灵敏度，基于碳的电化学传感器设计的新见解。这是通过探索导电性（Mg / Al）层状双氢氧化物-十二烷基硫酸盐/聚吡咯纳米复合材料的有趣特性而实现的，该复合材料是在（Mg / Al）层状双氢氧化物的组装过程中通过吡咯的原位聚合合成的，并采用阴离子表面活性剂十二烷基硫酸盐作为改性剂。纳米复合材料的形态和表面积的变化是吡咯百分比变化的结果。在最佳条件下，改性碳糊电极成功达到了0.057和0.134 nmol L ^-1的检出限盐酸特拉唑嗪在药物制剂和加标的人血清中的含量。此外，传感器是高度稳定的，可重复使用的，并且不受药物制剂中其他常见赋形剂的干扰。