Cutaneous squamous cell carcinoma (cSCC) is the second most common form of human cancer and has an increasing annual incidence. Although most cSCC is cured with office-based therapy, advanced cSCC poses a significant risk for morbidity, impact on quality of life, and death. This document provides evidence-based recommendations for the management of patients with cSCC. Topics addressed include biopsy techniques and histopathologic assessment, tumor staging, surgical and nonsurgical management, follow-up and prevention of recurrence, and management of advanced disease. The primary focus of these recommendations is on evaluation and management of primary cSCC and localized disease, but where relevant, applicability to recurrent cSCC is noted, as is general information on the management of patients with metastatic disease.

皮肤鳞状细胞癌（cSCC）是第二常见的人类癌症，并且每年的发病率不断增加。尽管大多数 cSCC 可以通过诊室治疗治愈，但晚期 cSCC 会带来显着的发病风险、对生活质量的影响和死亡。本文件为 cSCC 患者的管理提供基于证据的建议。讨论的主题包括活检技术和组织病理学评估、肿瘤分期、手术和非手术治疗、复发的随访和预防以及晚期疾病的治疗。这些建议的主要重点是原发性 cSCC 和局部疾病的评估和管理，但在相关的情况下，也指出了对复发性 cSCC 的适用性，以及转移性疾病患者管理的一般信息。