Effects of 1,8‐Cineole and (–)‐Linalool on Functional Brain Activation in a Working Memory Task,Flavour and Fragrance Journal

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Effects of 1,8‐Cineole and (–)‐Linalool on Functional Brain Activation in a Working Memory Task
Flavour and Fragrance Journal ( IF 2.1 ) Pub Date : 2018-01-10 , DOI: 10.1002/ffj.3436
Susanne Ambrosch ₁ , Claudia Duliban ₁ , Heike Heger ₁ , Ewald Moser ₂ , Elmar Laistler ₂ , Christian Windischberger ₂ , Eva Heuberger _{1,

3}

Affiliation

Several studies have shown the influence of fragrances on attentional functions and affective state in humans. The present study aimed to investigate the effects of the monoterpenoid compounds 1,8‐cineole and (–)‐linalool on the neuronal substrate of working memory, cognitive performance, physiological arousal, and affect. To this end, brain activation was assessed using functional magnetic resonance imaging (fMRI) in 69 young healthy adults while they performed a 1‐back task during inhalation or dermal application of one of the fragrances. The functional activation data of 51 subjects were included in the statistical analysis. Each condition was compared with an appropriate placebo condition without any fragrances. In addition, heart rate and respiration rate were measured. Before and after fMRI, affective state was assessed by means of rating scales. The results showed significant functional changes in brain areas related to working memory as a function of both fragrance and administration. Specifically, relative to placebo dermal application of 1,8‐cineole increased brain activation in the frontal cortex, whereas dermal (–)‐linalool increased cerebral blood flow in the basal ganglia. However, no such changes were observed after inhalation. In addition, dermal (–)‐linalool decreased error rate in the working memory task, while 1,8‐cineole did not affect performance. No effects of fragrance administration were detected on physiological arousal or affective state. These findings demonstrate that fragrances differentially affect brain activation and working memory in humans and emphasize the importance of the mode of administration when studying the effects of odorants on human cognition.

中文翻译：

1,8-Cineole和（–）-Linalool对工作记忆任务中功能性大脑激活的影响

多项研究表明，香料对人的注意力功能和情感状态有影响。本研究旨在研究单萜类化合物1,8-桉树脑和（-）-芳樟醇对工作记忆，认知功能，生理唤醒和影响的神经元基质的影响。为此，使用功能磁共振成像（f MRI）对69位年轻健康成年人的大脑激活进行了评估，而他们在吸入或经皮肤涂抹其中一种香精的过程中执行了一次背部锻炼。统计分析中包括51名受试者的功能激活数据。将每种情况与没有任何香料的适当安慰剂情况进行比较。另外，还测量了心率和呼吸率。f之前和之后MRI，通过评定量表评估情感状态。结果表明，与工作记忆有关的大脑区域功能发生了显着变化，这与香味和给药方式有关。具体而言，相对于安慰剂，经皮施用1,8-桉树脑可增加额叶皮层的大脑激活，而经皮（-）-芳樟醇可增加基底神经节的脑血流量。但是，吸入后未观察到此类变化。此外，真皮（-）-芳樟醇降低了工作记忆任务中的错误率，而1,8-桉树脑不影响性能。没有检测到芳香剂对生理唤醒或情感状态的影响。

更新日期：2018-01-10

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