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Back Cover: Regulation of Hedgehog Signaling in Cancer by Natural and Dietary Compounds
Molecular Nutrition & Food Research ( IF 5.2 ) Pub Date : 2018-01-10 , DOI: 10.1002/mnfr.201870015
Cheng Bao , Pavel Kramata , Hong Jin Lee , Nanjoo Suh

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Mol. Nutr. Food Res. 2018, 62, 1700621.

Aberrant Hh signaling can be regulated directly or indirectly by natural and dietary sources. Key Hh signaling mediators include Ptch, Smo, Gli and SuFu. In the presence of Hh ligands (HhN), the receptor Patched (Ptch) releases Smoothened (Smo) receptor which results in the activation of transcription factor Gli (Gli-A) to increase the expression of genes GLI1, CCND1, SNAI1, VEGF, BMP4 and others.



中文翻译:

封底:天然和饮食化合物对癌症中刺猬信号的调节

图形摘要的缩略图图像

大声笑 营养食品 食品水库。2018年,62,1700621。

异常的Hh信号传导可以通过自然和饮食来源直接或间接调节。关键的Hh信号传导介质包括Ptch,Smo,Gli和SuFu。在存在Hh配体(HhN)的情况下,修补的(Ptch)受体会释放平滑的(Smo)受体,从而激活转录因子Gli(Gli-A)从而增加基因GLI1,CCND1,SNAI1,VEGF, BMP4等。

更新日期:2018-01-10
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