CD4⁺ T cells that co-express CD25 and CD127 (CD25⁺ CD127⁺) make up around 20% of all circulating CD4⁺ memory T cells in healthy people. The clinical significance of these cells is that in children with type 1 diabetes their relative frequency at diagnosis is significantly and directly correlated with rate of disease progression. The purpose of this study was to further characterize the CD25⁺ CD127^hi cells. We show that they are a mix of Th1 and Th2 cells however, they have a significantly higher relative frequency of pre-committed and committed Th2 cells, and secrete significantly higher levels of Th2-type cytokines than CD25⁻ memory T cells. Further, these cells are neither exhausted nor senescent and proliferate to the same extent as CD25⁻ memory cells. Thus, CD25⁺ CD127^hi cells are a highly active subset of memory T cells that might play a role in controlling inflammation via anti-inflammatory Th2-type deviation.

CD4 ⁺ T细胞共表达CD25和CD127（CD25 ⁺  CD127 ⁺）占20％左右，全部循环的CD4 ⁺记忆T细胞的健康人。这些细胞的临床意义在于，在1型糖尿病患儿中，其诊断时的相对频率与疾病进展速度显着且直接相关。这项研究的目的是进一步表征CD25 ⁺  CD127 ^hi细胞。我们显示，它们是Th1和Th2细胞的混合物，但是它们具有相对较高的预先定型和定型Th2细胞相对频率，并且比CD25-分泌的Th2型细胞因子水平更高^。记忆T细胞。此外，这些细胞既不用尽也不衰老和增殖以相同的程度CD25 ^-存储器单元。因此，CD25 ⁺  CD127 ^hi细胞是记忆T细胞的高度活跃的子集，可能通过抗炎性Th2型变异在控制炎症中发挥作用。