Clinical Immunology ( IF 4.5 ) Pub Date : 2018-01-10 , DOI: 10.1016/j.clim.2018.01.003 Aditi Narsale , Rosita Moya , Joanna Davida Davies
CD4+ T cells that co-express CD25 and CD127 (CD25+ CD127+) make up around 20% of all circulating CD4+ memory T cells in healthy people. The clinical significance of these cells is that in children with type 1 diabetes their relative frequency at diagnosis is significantly and directly correlated with rate of disease progression. The purpose of this study was to further characterize the CD25+ CD127hi cells. We show that they are a mix of Th1 and Th2 cells however, they have a significantly higher relative frequency of pre-committed and committed Th2 cells, and secrete significantly higher levels of Th2-type cytokines than CD25− memory T cells. Further, these cells are neither exhausted nor senescent and proliferate to the same extent as CD25− memory cells. Thus, CD25+ CD127hi cells are a highly active subset of memory T cells that might play a role in controlling inflammation via anti-inflammatory Th2-type deviation.
中文翻译:
人CD4 + CD25 + CD127 hi细胞和Th1 / Th2表型
CD4 + T细胞共表达CD25和CD127(CD25 + CD127 +)占20%左右,全部循环的CD4 +记忆T细胞的健康人。这些细胞的临床意义在于,在1型糖尿病患儿中,其诊断时的相对频率与疾病进展速度显着且直接相关。这项研究的目的是进一步表征CD25 + CD127 hi细胞。我们显示,它们是Th1和Th2细胞的混合物,但是它们具有相对较高的预先定型和定型Th2细胞相对频率,并且比CD25-分泌的Th2型细胞因子水平更高。记忆T细胞。此外,这些细胞既不用尽也不衰老和增殖以相同的程度CD25 -存储器单元。因此,CD25 + CD127 hi细胞是记忆T细胞的高度活跃的子集,可能通过抗炎性Th2型变异在控制炎症中发挥作用。