Comparative studies on the hypolipidemic, antioxidant and hepatoprotective activities of catechin-enriched green and oolong tea in a double-blind clinical trial,Food & Function

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Comparative studies on the hypolipidemic, antioxidant and hepatoprotective activities of catechin-enriched green and oolong tea in a double-blind clinical trial
Food & Function ( IF 5.1 ) Pub Date : 2018-01-10 00:00:00 , DOI: 10.1039/c7fo01449j
Kamesh Venkatakrishnan _{1,

2,

3,

4} , Hui-Fang Chiu _{4,

5,

6,

7} , Ju-Chun Cheng _{1,

2,

3,

4} , Ya-Hui Chang _{1,

2,

3,

4} , Yan-Ying Lu _{2,

3,

4,

8} , Yi-Chun Han _{1,

2,

3,

4} , You-Cheng Shen _{2,

3,

4,

9} , Kun-Shun Tsai _{4,

10,

11,

12,

13} , Chin-Kun Wang _{1,

2,

3,

4}

Affiliation

This study aimed to compare the beneficial effect of catechin-enriched green tea and oolong tea on mildly hypercholesterolemic subjects. Sixty mildly hypercholesterolemic subjects (180–220 mg dL⁻¹) were enrolled and divided into three groups as catechin-enriched green tea (CEGT), catechin-enriched oolong tea (CEOT) or placebo. The subjects were instructed to drink 2 × 300 mL of CEGT (780.6 mg of catechin), CEOT (640.4 mg of catechin) or placebo beverage for 12 weeks. Drinking CEGT and CEOT significantly decreased (p < 0.05) the body weight, fat, and BMI, lipid peroxidation as well as lipid profile (TC, LDL-c, HDL-c, and TG). Also, intervention with CEGT and CEOT significantly improved (p < 0.05) the oxidative indices (TEAC and GSH) and antioxidant enzymes (SOD, CAT, GPx, and GR). Moreover, ultrasound examination endorsed the hepatoprotective activity of CEGT and CEOT by reverting mild fatty liver to the normal hepatic condition because of antioxidant and hypolipidemic activities. To summarize, both CEGT and CEOT showed similar antioxidant and hepatoprotective activities. However, CEOT displayed superior lipid-lowering activity compared to CEGT or placebo, and hence it could be used to amend the wellness condition of mildly hypercholesterolemic subjects.

中文翻译：

一项富含双儿茶素的富含儿茶素的绿茶和乌龙茶的降血脂，抗氧化和保肝活性的比较研究

这项研究旨在比较富含儿茶素的绿茶和乌龙茶对轻度高胆固醇血症受试者的有益作用。招募了60名轻度高胆固醇血症受试者（180-220 mg dL ^-1），分为三类，即富含儿茶素的绿茶（CEGT），富含儿茶素的乌龙茶（CEOT）或安慰剂。指示受试者喝2×300 mL的CEGT（780.6 mg儿茶素），CEOT（640.4 mg儿茶素）或安慰剂饮料12周。饮用CEGT和CEOT可以显着降低（p <0.05）体重，脂肪和BMI，脂质过氧化以及脂质分布（TC，LDL-c，HDL-c和TG）。此外，对CEGT和CEOT的干预也大大改善了（p<0.05）的氧化指数（TEAC和GSH）和抗氧化酶（SOD，CAT，GPx和GR）。此外，由于抗氧化和降血脂作用，超声检查通过将轻度脂肪肝恢复到正常的肝脏状态，从而支持了CEGT和CEOT的保肝活性。总而言之，CEGT和CEOT均显示出相似的抗氧化和保肝活性。但是，与CEGT或安慰剂相比，CEOT显示出更好的降脂活性，因此它可用于改善轻度高胆固醇血症受试者的健康状况。

更新日期：2018-01-10

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