Polysaccharide, as a promising candidate to meet the medication requirement of ulcerative colitis (UC), is increasingly attracting extensive interest. Dendrobium officinale has been widely used to treat gastrointestinal sickness in the clinical treatment of Traditional Chinese Medicine. However, it remains largely unknown whether polysaccharides (DOPS) from Dendrobium officinale can treat UC. The purpose of this paper is to confirm therapeutic action of DOPS to UC and explored its underlying mechanisms. We noted that DOPS could dramatically improve clinical signs and symptoms, decrease mortality, alleviate colonic pathological damage, and reestablish the balance of pro- and anti-inflammatory cytokines in DSS-induced acute UC mice. Moreover, DOPS treatment could also markedly suppress the activation of NLRP3 inflammasome and β-arrestin1 in vivo and in vitro. This study showed that DOPS possesses appreciable therapeutic effect to treat experimental acute UC mice. Its mechanism could be related to inhibition of NLRP3 inflammasome and β-arrestin1 signaling pathways.

多糖作为满足溃疡性结肠炎（UC）药物需求的有前途的候选者，越来越引起人们的广泛关注。铁皮石end已被广泛用于中医临床治疗胃肠道疾病。然而，它在很大程度上仍然未知是否多糖（DOPS）铁皮石斛可以治疗UC。本文的目的是确认DOPS对UC的治疗作用并探讨其潜在机制。我们注意到，DOPS可以显着改善临床症状和体征，降低死亡率，减轻结肠病理损害，并在DSS诱导的急性UC小鼠中重新建立促炎和消炎细胞因子的平衡。此外，DOPS治疗还可以在体内和体外显着抑制NLRP3炎性小体和β-arrestin1的活化。这项研究表明，DOPS对治疗实验性急性UC小鼠具有明显的治疗作用。其机制可能与抑制NLRP3炎性体和β-arrestin1信号通路有关。