A quantitative analysis has cast doubt over the limited advantages provided by particles for nose-to-brain (NTB) drug delivery. Thus, it is imperative to identify the role of nanovehicles in NTB drug delivery. If nanocarriers are used merely as an option to improve various properties of the drugs or the formulations, it is difficult for them to outperform conventional formulations, such as solutions or gels. However, nanovehicles bring about special features, such as maintenance of the solubilized state of drugs, sustained or delayed release, and enhanced penetration because of surface modifications, all of which lead to enhanced NTB delivery efficiency.

中文翻译：

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纳米车辆在鼻到脑给药中的作用的最新进展

定量分析使人们怀疑颗粒物可用于鼻-脑（NTB）药物输送的有限优势。因此，必须确定纳米载体在NTB药物递送中的作用。如果仅将纳米载体用作改善药物或制剂的各种性质的选择，则它们难以胜过常规制剂，例如溶液或凝胶。然而，纳米载体带来特殊的功能，例如维持药物的溶解状态，持续或延迟释放以及由于表面修饰而增加的渗透性，所有这些都导致NTB递送效率的提高。