The overuse of antibiotics has posed a propagation of antibiotic resistance genes (ARGs) in aquaculture systems. This study firstly explored the ARGs profiles of the typical mariculture farms including conventional and recirculating systems using metagenomics approach. Fifty ARGs subtypes belonging to 21 ARGs types were identified, showing the wide-spectrum profiles of ARGs in the coastal industrial mariculture systems. ARGs with multiple antibiotics resistance have emerged in the mariculure systems. The co-occurrence pattern between ARGs and microbial taxa showed that Proteobacteria and Bacteroidetes were potential dominant hosts of ARGs in the industrial mariculture systems. Typical nitrifying bacteria such as Nitrospinae in mariculture systems also carried with some resistance genes. Relative abundance of ARGs in fish ponds and wastewater treatment units was relatively high. The investigation showed that industrial mariculture systems were important ARGs reservoirs in coastal area, indicating the critical role of recirculating systems in the terms of ARGs pollution control.

抗生素的过度使用已导致在水产养殖系统中传播抗生素抗性基因（ARG）。这项研究首先使用宏基因组学方法探讨了典型海水养殖场的ARGs概况，包括常规和再循环系统。确定了属于21种ARGs类型的50种ARGs亚型，显示了沿海工业海水养殖系统中ARGs的广谱分布。在海水养殖系统中出现了对多种抗生素具有抗药性的ARGs。ARGs和微生物类群之间的共现模式表明，Proteobacteria和拟杆菌属是工业海水养殖系统中ARGs的潜在优势宿主。海水养殖系统中的典型硝化细菌（如硝基棘）也带有一些抗性基因。鱼塘和废水处理单元中ARG的相对丰度相对较高。调查表明，工业海水养殖系统是沿海地区重要的ARGs库，这表明再循环系统在ARGs污染控制方面具有关键作用。