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Effects of carotenoids on lipid bilayers†
Physical Chemistry Chemical Physics ( IF 2.9 ) Pub Date : 2018-01-09 00:00:00 , DOI: 10.1039/c7cp07126d Quentin R. Johnson 1, 2, 3, 4, 5 , Barmak Mostofian 4, 5, 6, 7 , Gabriel Fuente Gomez 2, 3, 4, 8 , Jeremy C. Smith 4, 5, 6, 7, 8 , Xiaolin Cheng 4, 5, 6, 7
Physical Chemistry Chemical Physics ( IF 2.9 ) Pub Date : 2018-01-09 00:00:00 , DOI: 10.1039/c7cp07126d Quentin R. Johnson 1, 2, 3, 4, 5 , Barmak Mostofian 4, 5, 6, 7 , Gabriel Fuente Gomez 2, 3, 4, 8 , Jeremy C. Smith 4, 5, 6, 7, 8 , Xiaolin Cheng 4, 5, 6, 7
Affiliation
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Carotenoids have been found to be important in improving the integrity of biomembranes in eukaryotes. However, the molecular details of how carotenoids modulate the physical properties of biomembranes are unknown. To this end, we have conducted a series of molecular dynamics simulations of different biologically-relevant membranes in the presence of carotenoids. The carotenoid effect on the membrane was found to be specific to the identity of the carotenoid and the composition of the membrane itself. Therefore, different classes of carotenoids produce a different effect on the membrane, and different membrane phases are affected differently by carotenoids. It is apparent from our data that carotenoids do trigger the bilayer to become thinner. The mechanism by which this occurs depends on two competing factors, the ability of the lipid tails of opposing monolayers to either (1) compress or (2) interdigitate as the bilayer condenses. Indeed, carotenoids directly influence the physical properties via these two mechanisms, thus compacting the bilayer. However, the degree to which these competing mechanisms are utilized depends on the bilayer phase and the carotenoid identity.
中文翻译：
类胡萝卜素对脂质双层的影响†
已经发现类胡萝卜素对于改善真核生物中生物膜的完整性很重要。然而，类胡萝卜素如何调节生物膜的物理特性的分子细节是未知的。为此，我们在类胡萝卜素存在下对不同生物相关膜进行了一系列分子动力学模拟。发现对膜的类胡萝卜素效应是特定于类胡萝卜素的特性和膜本身的组成的。因此，不同种类的类胡萝卜素对膜产生不同的作用，并且不同的膜相受类胡萝卜素的影响不同。从我们的数据可以明显看出，类胡萝卜素确实会触发双层变薄。发生这种情况的机制取决于两个相互竞争的因素，相对的单层脂质尾部在双层凝结时（1）压缩或（2）相互交叉的能力。确实，类胡萝卜素直接影响物理性质通过这两种机制，从而压实了双层。但是，利用这些竞争机制的程度取决于双层相和类胡萝卜素的身份。
更新日期：2018-01-09
中文翻译：
类胡萝卜素对脂质双层的影响†
已经发现类胡萝卜素对于改善真核生物中生物膜的完整性很重要。然而，类胡萝卜素如何调节生物膜的物理特性的分子细节是未知的。为此，我们在类胡萝卜素存在下对不同生物相关膜进行了一系列分子动力学模拟。发现对膜的类胡萝卜素效应是特定于类胡萝卜素的特性和膜本身的组成的。因此，不同种类的类胡萝卜素对膜产生不同的作用，并且不同的膜相受类胡萝卜素的影响不同。从我们的数据可以明显看出，类胡萝卜素确实会触发双层变薄。发生这种情况的机制取决于两个相互竞争的因素，相对的单层脂质尾部在双层凝结时（1）压缩或（2）相互交叉的能力。确实，类胡萝卜素直接影响物理性质通过这两种机制，从而压实了双层。但是，利用这些竞争机制的程度取决于双层相和类胡萝卜素的身份。
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