Three-component difluoroalkylation and trifluoromethylthiolation/trifluoromethylselenolation of π-bonds,Chemical Communications

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Three-component difluoroalkylation and trifluoromethylthiolation/trifluoromethylselenolation of π-bonds
Chemical Communications ( IF 4.3 ) Pub Date : 2018-01-09 00:00:00 , DOI: 10.1039/c7cc09083h
Bo-Sheng Zhang _{1,

2,

3,

4} , Lu-Yao Gao _{1,

2,

3,

4} , Zhe Zhang _{1,

2,

3,

4} , Yu-Hua Wen _{1,

2,

3,

4} , Yong-Min Liang _{1,

2,

3,

4}

Affiliation

This report describes a new method for three-component difluoroalkylation and trifluoromethylthiolation/trifluoromethylselenolation of π-bonds via air-stable SCF₃ and SeCF₃ reagents as free-radical initiators of ethyl iododifluoroacetate. β-Proton elimination can be overcome effectively in this reaction system, and a broad substrate scope, including alkenes and alkynes, makes this approach practical and attractive.

中文翻译：

π键的三组分二氟烷基化和三氟甲基硫醇化/三氟甲基硒化

该报告描述了一种新的方法，该方法通过空气稳定的SCF ₃和SeCF ₃试剂作为碘代二氟乙酸乙酯的自由基引发剂，对三键进行三组分二氟烷基化和三氟甲基硫醇化/三氟甲基硒化。在该反应系统中可以有效克服β-质子的消除，并且广泛的底物范围（包括烯烃和炔烃）使该方法实用且有吸引力。

更新日期：2018-01-31

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